CUH CCU Heparin Protocol

  • For continuous IV infusion initiate at 1000 iu/hr aiming to maintain APTT between 60 - 90 seconds (will need 4-6 hourly APTT)
  • Usually give a bolus of 5,000 iu IV before starting infusion
  • If APTT >100 seconds: stop infusion for 1 hour or reduce infusion rate by 100 iu/hr, repeating APTT 4 hours post infusion change

Infusion protocol
APTT Action
<20 Bolus 5000 iu and increase by 100 iu/hr
20 - 40 Increase by 200 iu/hr
40 - 60 Increase by 100 iu/hr
60 - 90 Continue same infusion
90 - 100 Decrease by 100 iu/hr