Solvent Detergent Plasma



Background

The information on this page was selected from an Information Leaflet produced by the National Haemovigilance Office, issued in January 2003.

  • Anaphylactic or anaphylactoid reactions due to hypersensitivity to infused plasma proteins or anti-IgA following the transfusion of Solvent Detergent Plasma (SDP) are rare (<1: 1000) and are likely to be of the same order as for FFP.

The usual starting dose of SDP is 12-15 mls/Kg.

  • Monitor the response both clinically and with measurement of prothrombin time (PT), partial thromboplastin time (PTT)
  • The infusion of SDP should begin as soon as clinical circumstances permit after thawing.
  • Beware volume overload if rapid infusion is used in patients with limited cardiac reserve. (max rate 2-4mls/kg per hour in such patients)
  • Each unit of SDP contains a standard volume of 200mls, in contrast to a unit of FFP, which contains 220-300mls.
  • Plasma therapy should only be given where there is a clear clinical indication and where the expected benefit outweighs the inherent risks.

Firm indications for giving plasma include:

  • The correction of haemostatic disorders where no other more suitable therapy exists or is available
  • Emergency warfarin reversal where prothrombin complex concentrates are unavailable (see Mx over-anticoagulation or in left border)

SDP is only required for the reversal of over anticoagulation in the presence of major bleeding.

Reversal of bleeding in patients on DOACs (Direct Oral Anticoagulants) must be discussed wit haematology team. A reversal agent is available in CUH for Dabigatran (Pradaxa) - on clinical trial only - contact haematology SpR.

  • Haemostatic failure associated with major blood loss
  • Liver disease, either in the presence of haemorrhage, or prior to an elective procedure
  • Acute Disseminated Intravascular Coagulation
  • Factor V deficiency and acetyl cholinesterase deficiency
  • The treatment of choice in thrombotic thrombocytopaenia purpura (TTP) in conjunction with plasma exchange


  • Content by Dr Íomhar O' Sullivan 02/12/2004. Reviewed 05/03/2007. Last review Dr Susan O’Shea, Dr ÍOS November 22, 2018.