Cellulitis
Infection |
Osteomyelitis and septic arthritis |
| Most likely organisms | S aureus, group A Streptococci and other Streptococci. |
|---|---|
| Empiric treatment | Flucloxacillin 2g q6h iv Consider addition of Fusidic acid (sodium fusidate) 500mg q8h po for confirmed S. aureus infection. |
| In penicillin allergy | Vancomycin 25mg/kg (max 2g) loading dose then 15mg/kg q12h iv. Consider addition of Fusidic acid (sodium fusidate) 500mg q8h po for confirmed S. aureus infection. Vancomycin pre-dose level: aim for 15-20mg/L. |
| Duration | Septic arthritis: 4-6 weeks, IV for 14 days. Osteomyelitis: 6 weeks (although may require up to 3 months), iv therapy for 14-21 days. Shorter duration of iv if responding - e.g. iv therapy for minimum 7 days. |
| Comments | Always seek advice from microbiology or infections diseases. |
Appendices
- Appendix 1 Switching from IV to PO therapy
- Appendix 2 Aminoglycoside monitoring
- Appendix 3 Vancomycin
- Appendix 4 Clostridium difficile diarrhoea
- Appendix 5 MRSA
- Appendix 6 Renal impairment, antibiotics
- Appendix 7 IV preparations
- Appendix 8 Prescribing Tips
- Prophylaxis - Endocarditis
- Prophylaxis - Meningitis
- Prophylaxis - Post Splenectomy /Hyposplenic
- Penicillin Allergy
- SEPSIS.