- Dx based on pin-point pupils, respiratory depression, drowsiness or coma
- Pupils may be dilated if the patient is hypothermic, hypotensive (e.g. secondary to opioids), hypoxic
- Convulsions and pulmonary oedema may develop
- Therapeutic trail of IM Naloxone ( short-acting and repeated doses/infusion required)
- Naloxone can be delivered Intra-nasally, as a Nebuliser or Intramuscularly
- Nebulised is an option when the patient is relatively stable (as long as the patient had some spontaneous respiratory effort and no severe cardiorespiratory compromise. (Ref))
- Naloxone should only be given IV in cases requiring multiple doses of Naloxone (e.g. methadone OD). Start an IV Naloxone infusion at 1/3 the first hours requirements per hour.
0.4mg aliquots up to 2mg
2 mg (2 ml) of Naloxone and attach nasal atomizer (details).
Nebulisation of 2 mg of Naloxone with 3 mL of normal saline
Start an IV Naloxone infusion at 1/3 the first hours requirements per hour.