Toxidromes



Anticholinergic

Blind as a bat, mad as a hatter, red as a beet, hot as a hare, dry as a bone, the bowel and bladder lose their tone, and the heart runs alone.

Clinical

  • Blurred vision, dry skin, fever, flushing
  • Ileus, urinary retention
  • Tachycardia, hypertension, hyperthermia
  • Mydriasis, myoclonus, seizures
  • Coma, delirum, hallucinations, amnesia

Causes

Antihistamines, antipsychotics, antidepressants, antiparkinsonian drugs, atropine, benztropine.

Cholinergic

DUMBBELLSS: Diarrhoea, Urination, Miosis, Bradycardia, Bronchospasm, Emesis, Lacrimation, Lethargy, Salivation and Seizures.

Most deaths from bradycardia, and bronchospasm/bronchorrhoea.

Clinical

  • Bronchorrhoea, confusion, defecation, diaphoresis, diarrhoea, emesis, lacrimation, miosis, muscle fasciculations, salivation, seizures, urination, and weakness. Complications include bradycardia, hypothermia, and tachypnea.

Causes

Reversal



Content By Dr Íomhar O' Sullivan 12/03/2017. Last review Dr ÍOS 9/11/18.