VIPIT



Background

  • Thrombocytopenia & thrombosis, like heparin induced thrombocytopenia (HIT) post AstraZeneca Covid-19 vaccine.
  • Very rare.

Approach



References

  1. https://www.medicines.ie/medicines/covid-19-vaccine-astrazeneca-35051/spc (accessed 06/04/2021).
  2. British Society of Haematology Guidance produced from the Expert Haematology Panel (EHP) focussed on syndrome of Thrombosis and Thrombocytopenia occurring after coronavirus Vaccination: Updated Guidance on Management. Version 1.0 (accessed on 03/04/2021) https://b-s-h.org.uk/media/19512/guidance-version-10-on-mngmt-of-thrombosis-with-thrombocytopenia-occurring-after-c-19-vaccine_20210401.pdf.
  3. Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle P, Eichinger S. A Prothrombotic Thrombocytopenic Disorder Resembling Heparin-Induced Thrombocytopenia Following Coronavirus-19 Vaccination. Research Square Preprint. DOI: https://doi.org/10.21203/rs.3.rs-362354/v1
  4. Pai M, Grill A, Ivers N, et al. Vaccine-induced prothrombotic immune thrombocytopenia VIPIT following AstraZeneca COVID-19 vaccination. Science Briefs of the Ontario COVID-19 Science Advisory Table. 2021;1(17). https://doi.org/10.47326/ocsat.2021.02.17.1.0.
  5. Vaccine-Induced Prothrombotic Immune Thrombocytopenia (VIPIT) following AstraZeneca COVID-19 Vaccination: Interim Guidance for Healthcare Professionals in Emergency Department and Inpatient Settings. Menaka Pai, Michael Schull, Fahad Razak, Allan Grill, Noah Ivers, Antonina Maltsev, Katherine J. Miller, Brian Schwartz, Nathan M. Stall, Robert Steiner, Sarah Wilson, Ullanda Niel, Peter Jüni, Andrew M. Morris on behalf of the Drugs & Biologics Clinical Practice Guidelines Working Group and the Ontario COVID-19 Science Advisory Table. Version 1.0 (Accessed 02/04/2021) https://doi.org/10.47326/ocsat.2021.02.21.1.0.
  6. Diagnosis and Management of Vaccine-Related Thrombosis following AstraZeneca COVID-19 Vaccination: Guidance Statement from the GTH. Johannes Oldenbur, Robert Klamroth, Florian Langer, Manuela Albisetti, Charis von Auer, Cihan Ay, Wolfgang Korte, Rüdiger E. Scharf, Bernd Pötzsch, Andreas Greinacher. Hämostaseologie 30/03/2021. DOI https://doi.org/10.1055-a/1469-7481.(Page no longer exists).
  7. https://www.ema.europa.eu/en/news/astrazenecas-covid-19-vaccine-ema-finds-possible-link-very-rare-cases-unusual-blood-clots-low-blood (accessed 07/04/2021).

Content Cork EM Consultants. Last review Dr ÍOS 10/06/21.