Enoxaparin (Clexane®)



Background

  • Enoxaparin is a LMWH used for the prophylaxis of DVT and ischemic complications of unstable angina & NSTEMI
  • Also used for the treatment of VTE
  • Administered as subcutaneous injection

Dosing

Thromboprophylaxis

Enoxaparin (Clexane®) thromboprophylaxis
CrCl Weight
<50 Kg 50-100 Kg 101-150 Kg >150 Kg
>30ml/min 20mg (2000 units) OD sc 40mg (4000 units) OD sc 40mg (4000 units) BD sc 60mg (6000 units) BD sc
15-30ml/min 20mg (2000 units) OD sc 20mg (2000 units) OD sc 40mg (4000 units) OD sc 60mg (6000 units) OD sc
<15ml/min Consultant Decision 20mg (2000 units) OD sc 20mg (2000 units) OD sc Consultant Decision

VTE (PE or DVT) management

Enoxaparin (Clexane®) dose guidance for DVT & PE treatment in ADULTS
CrCl > 30ml/min Enoxaparin 1.5mg/kg (150units/kg) OD sc
or
Enoxaparin 1mg/kg (100units/kg) BD sc
The regimen should be selected by the physician based on an individual assessment including evaluation of the thromboembolic risk and of the risk of bleeding
CrCl 15-30ml/min Enoxaparin 1mg/kg (100units/kg) OD sc
CrCl<15ml/min Consultant decision


Content by Dr Íomhar O' Sullivan. Last review Dr ÍOS 23/12/22.