Background
- Tranexamic acid should be used in in adult trauma patients at risk of significant bleeding.[CRASH-2 RCT Lancet 2010].
- CRASH-2 - Tranexamic acid v placebo : Risk of death from bleeding reduced [4·9%] vs [5·7%]; (RR 0·85, 95% CI 0·76–0·96)
- Tranexamic acid loading dose 1 g over 10 min then infusion of 1 g over 8 hours